咨询与建议

限定检索结果

文献类型

  • 2,130 篇 期刊文献
  • 38 篇 会议

馆藏范围

  • 2,168 篇 电子文献

日期分布

学科分类号

  • 1,334 篇 理学
    • 1,161 篇 生物科学类
    • 171 篇 化学类
    • 2 篇 物理学类
  • 1,209 篇 农学
    • 45 篇 植物生产类
  • 291 篇 医学
    • 120 篇 药学类
    • 77 篇 临床医学类
    • 65 篇 基础医学
    • 15 篇 公共卫生预防医学...
    • 12 篇 中医学类
    • 4 篇 中药学类
  • 283 篇 教育学
  • 45 篇 工学
    • 33 篇 环境科学与工程类
    • 8 篇 计算机类
    • 2 篇 化工与制药类
    • 1 篇 机械学
    • 1 篇 生物工程类

主题

  • 2,168 篇 structure-activi...
  • 2,070 篇 relationship
  • 947 篇 molecular
  • 928 篇 animals
  • 748 篇 protein
  • 684 篇 &
  • 636 篇 humans
  • 617 篇 acid
  • 600 篇 sequence
  • 541 篇 amino
  • 492 篇 binding
  • 455 篇 data
  • 447 篇 effects
  • 444 篇 models,
  • 422 篇 conformation
  • 412 篇 cell
  • 390 篇 kinetics
  • 321 篇 sites
  • 282 篇 drug
  • 233 篇 rats

机构

  • 5 篇 department of bi...
  • 5 篇 department of ch...
  • 3 篇 department of ch...
  • 3 篇 these authors co...
  • 2 篇 department of bi...
  • 2 篇 department of ch...
  • 2 篇 department of ch...
  • 2 篇 department of ch...
  • 2 篇 department of ch...
  • 2 篇 department of mo...
  • 2 篇 faculty of chemi...
  • 2 篇 institute of mol...
  • 2 篇 mrc laboratory o...
  • 2 篇 school of pharma...
  • 1 篇 center for appl...
  • 1 篇 center for inte...
  • 1 篇 core research f...
  • 1 篇 department of a...
  • 1 篇 department of b...
  • 1 篇 department of b...

作者

  • 11 篇 jr.
  • 4 篇 rui wang
  • 3 篇 chien ho
  • 3 篇 daniel v. santi
  • 3 篇 gary l. nelsestu...
  • 3 篇 iii
  • 2 篇 brenk, ruth
  • 2 篇 corwin hansch
  • 2 篇 ezzat s. younath...
  • 2 篇 juan wang
  • 2 篇 kevin m. smith
  • 2 篇 lewis, d. f. v.
  • 2 篇 parmar, virinder...
  • 2 篇 prasad, ashok k.
  • 2 篇 robert m. stroud
  • 2 篇 ronald j. voll
  • 2 篇 sawyer w.h.
  • 2 篇 schultz, peter g...
  • 2 篇 siamak a. adibi
  • 2 篇 victor j hruby

语言

  • 2,083 篇 英文
  • 75 篇 中文
  • 10 篇 法文
检索条件"主题词=Structure-Activity"
2168 条 记 录,以下是1-10 订阅
排序:
Structure-Activity relationships regarding the antioxidant effects of the flavonoids on human erythrocytes
收藏 引用
自然科学期刊(英文) 2012年 第9期4卷 740-747页
作者: Yousif Y. Bilto Sanaa Suboh Talal Aburjai Shtywy Abdalla Department of Biological Sciences University of Jordan Amman Jordan Faculty of Pharmacy University of Jordan Amman Jordan
The effects of eleven flavonoids on lipid peroxidation, protein degradation, deformability and osmotic fragility of human erythrocytes exposed in vitro to 10 mM H2O2 for 60 min at 37 oC have been studied. The followin... 详细信息
来源: 维普期刊数据库 维普期刊数据库 评论
HIV subtypes and recombination strains-strategies for induction of immune responses in man
收藏 引用
Vaccine 2002年 第15期20卷 1988-1993页
作者: Wahren, B. britta.wahren@smi.ki.se Ljungberg, K. Rollman, E. Levi, M. Zuber, B. Kjerrström Zuber, A. Hinkula, J. Leandersson, A.-C. Calarota, S. Hejdeman, B. Bratt, G. Sandström, E. Swedish Institute for Infectious Disease Control Department of Venereology South Hospital Karolinska Institute 171 82 Stockholm Sweden. britta.wahren@smi.ki.se
Clinical and experimental studies of HIV-1 subcomponents were made in order to increase their immunogenicity. HIV subtype envelopes A, B and C have been compared and a detailed analysis made by peptides of the corecep... 详细信息
来源: ElsevierScienceDirect期刊 ElsevierScienceDirec... EBSCOASC期刊 EBSCOASC期刊 评论
Enhanced protein thermostability from designed mutations that interact with α-helix dipoles
收藏 引用
Nature 1988年 第6200期336卷 651-656页
作者: H. Nicholson W. J. Becktel B. W. Matthews Institute of Molecular Biology Departments of Physics and Chemistry University of Oregon Eugene OR 97403 United States
Two different genetically engineered amino-acid substitutions designed to interact with α-helix dipoles in T4 lysozyme are shown to increase the thermal stability of the protein. Crystallographic analyses of the muta... 详细信息
来源: Nature在线期刊 Nature在线期刊 评论
Novel Five‐Membered Iminocyclitol Derivatives as Selective and Potent Glycosidase Inhibitors: New Structures for Antivirals and Osteoarthritis
收藏 引用
ChemBioChem;Chembiochem 2006年 第1期7卷 165–173页
作者: Pi‐Hui Liang Dr. Wei‐Chieh Cheng Dr. Yi‐Ling Lee Han‐Pang Yu Ying‐Ta Wu Dr. Yi‐Ling Lin Dr. Chi‐Huey Wong Prof. The Genomics Research Center and Institute of Biomedical Sciences Academia Sinica No. 128 Academia Road Sec. 2 Nankang District Taipei 11529 Taiwan Fax: (+886) 2-2785-8847 The Genomics Research Center and Institute of Biomedical Sciences Academia Sinica No. 128 Academia Road Sec. 2 Nankang District Taipei 11529 Taiwan Fax: (+886) 2-2785-8847 The Genomics Research Center and Institute of Biomedical Sciences Academia Sinica No. 128 Academia Road Sec. 2 Nankang District Taipei 11529 Taiwan Fax: (+886) 2-2785-8847 The Genomics Research Center and Institute of Biomedical Sciences Academia Sinica No. 128 Academia Road Sec. 2 Nankang District Taipei 11529 Taiwan Fax: (+886) 2-2785-8847 The Genomics Research Center and Institute of Biomedical Sciences Academia Sinica No. 128 Academia Road Sec. 2 Nankang District Taipei 11529 Taiwan Fax: (+886) 2-2785-8847 The Genomics Research Center and Institute of Biomedical Sciences Academia Sinica No. 128 Academia Road Sec. 2 Nankang District Taipei 11529 Taiwan Fax: (+886) 2-2785-8847 The Genomics Research Center and Institute of Biomedical Sciences Academia Sinica No. 128 Academia Road Sec. 2 Nankang District Taipei 11529 Taiwan Fax: (+886) 2-2785-8847 Department of Chemistry and Skaggs Institute for Chemical Biology The Scripps Research Institute 10550 North Torrey Pines Road La Jolla CA 92037 USA Fax: (+1) 858-784-2409
A novel 5-membered iminocyclitol derivative was found to be a potent and selective inhibitor of the glycoprotein-processing α-glucosidase with a K1 value of 53 nM. This compound was further derivatized to antiviral a... 详细信息
来源: Wiley期刊 Wiley期刊 评论
Conjugated methyl sulfide and phenyl sulfide derivatives of oxidosqualene as inhibitors of oxidosqualene and squalene‐hopene cyclases
收藏 引用
Lipids 2003年 第3期38卷 201-207页
作者: Flavio Rocco Simonetta Oliaro Bosso Franca Viola Paola Milla Giorgio Roma Giancarlo Grossi Maurizio Ceruti Dipartimento di Scienza e Tecnologia del Farmaco Università degli Studi di Torino Torino Italy
Various (1E,3E)- and (1Z,3E)-conjugated methylthio derivatives of oxidosqualene (OS) and conjugated and non-conjugated phenylthio derivatives of OS were obtained. These compounds, designed as inhibitors of pig liver a... 详细信息
来源: Wiley期刊 Wiley期刊 springerlink期刊 springerlink期刊 评论
Inhibition of dihydropteridine reductase by novel 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs
收藏 引用
Science 1984年 第4647期224卷 405-407页
作者: Creed W. Abell Rong-Sen Shen Wieslaw Gessner Arnold Brossi Department of Human Biological Chemistry and Genetics Division of Biochemistry University of Texas Medical Branch Galveston 77550 Laboratory of Chemistry National Institute of Arthritis Diabetes and Digestive and Kidney Diseases National Institutes of Health Bethesda MD 20205 United States
Hydroxylated derivatives of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a nigrostriatal neurotoxin in humans and primates, noncompetitively inhibited dihydropteridine reductase from human liver and rat striat... 详细信息
来源: 《科学》杂志 评论
DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9
收藏 引用
Cell 1989年 第7期57卷 1275-1283页
作者: Steven D. Hanes Roger Brent Department of Molecular Biology Massachusetts General Hospital Boston Massachusetts 02114 USA Department of Genetics Harvard Medical School Boston Massachusetts 02115 USA Department of Molecular Biology Massachusetts General Hospital Boston Massachusetts 02114 USA Department of Genetics Harvard Medical School Boston Massachusetts 02115 USA
Formation of anterior Structures in the Drosophila embryo requires the product of the genebicoid. Thebicoidprotein contains a homeodomain and may exert its effects in early development by regulating tr... 详细信息
来源: ElsevierScienceDirect期刊 ElsevierScienceDirec... cell期刊 评论
The structural basis of protein acetylation by the p300/CBP transcriptional coactivator
收藏 引用
Nature 2008年 第7180期451卷 846-850页
作者: Xin Liu Ling Wang Zhao, Kehao Thompson, Paul R. Hwang, Yousang Marmorstein, Ronen marmor@wistar.org Cole, Philip A. pcole@jhmi.edu These authors contributed equally to this work. These authors contributed equally to this work. Present addresses: Novartis Institute for Biomedical Research Cambridge Massachusetts 02139 USA (K.Z.) Department of Chemistry and Biochemistry University of South Carolina 631 Sumter Street Columbia South Carolina 29208 USA (P.R.T.) Present addresses: Novartis Institute for Biomedical Research Cambridge Massachusetts 02139 USA (K.Z.) Department of Chemistry and Biochemistry University of South Carolina 631 Sumter Street Columbia South Carolina 29208 USA (P.R.T.) Department of Pharmacology and Molecular Sciences Johns Hopkins University School of Medicine 725 North Wolfe Street Baltimore Maryland 21205 USA Department of Chemistry University of Pennsylvania Philadelphia Pennsylvania 19104 USA Department of Pharmacology and Molecular Sciences Johns Hopkins University School of Medicine 725 North Wolfe Street Baltimore Maryland 21205 USA
The transcriptional coactivator p300/CBP (CREBBP) is a histone acetyltransferase (HAT) that regulates gene expression by acetylating histones and other transcription factors. Dysregulation of p300/CBP HAT Activity con... 详细信息
来源: EBSCOASC期刊 EBSCOASC期刊 Nature在线期刊 Nature在线期刊 评论
Conformation-dependent nitration of the protein activator of cyclic adenosine 3',5'-monophosphate phosphodiesterase
收藏 引用
Biochemistry 1978年 第5期17卷 928-935页
作者: Paul G. Richman Claude B. Klee The Laboratory of Biochemistry National Cancer Institute National Institutes of Health Bethesda Maryland 20014 United States
The conformational transition observed upon binding of Ca2+ to the Ca2+-dependent activator protein of cyclic adenosine 3’,5'-monophosphate phosphodiesterase is reflected in a change in reActivity of its two tyrosine... 详细信息
来源: 美国化学学会(ACS)期刊... 评论
Biostructural analysis of the metal-sensor domain of CnrX from Cupriavidus metallidurans CH34
收藏 引用
Antonie van Leeuwenhoek;Antonie Van Leeuwenhoek 2009年 第2期96卷 141-141页
作者: Guillaume Pompidor Eric Girard Antoine Maillard Stéphanie Ramella-Pairin Beate Bersch Richard Kahn Jacques Covès Laboratoire des Protéines MembranairesInstitut de Biologie Structurale—Jean-Pierre Ebel UMR 5075 CNRS-CEA-UJFGrenoble CedexFrance Laboratoire de Résonance Magnétique NucléaireInstitut de Biologie Structurale—Jean-Pierre Ebel UMR 5075 CNRS-CEA-UJFGrenoble CedexFrance
In Cupriavidus metallidurans CH34, the proteins CnrX, CnrY, and CnrH regulate the expression of the cnrCBA operon that codes for a cation-efflux pump involved in cobalt and nickel resistance. The periplasmic part of C... 详细信息
来源: springerlink期刊 springerlink期刊 评论